Biodegradable Nanoparticles Composition

Biodegradable nanoparticles based on a biodegradable homopolymer of C2–C6 alkyl 2-cyanoacrylate monomers selected from ethyl 2-cyanoacrylate and n-butyl 2-cyanoacrylate, the nanoparticles comprising a non-covalent insulin complex encapsulated therein along with a pharmaceutically acceptable stabilizer being pectin, wherein at least 90 % of the nanoparticles have a hydrodynamic diameter between 100 nm and 300 nm as measured by dynamic light scattering and comprise 10 to 30 % by weight of insulin relative to the total weight of the nanoparticles